Neuropathic Pain

Nervous System affected

Neuropathic pains are characterised by partial or complete somatosensory change in the innervation territory corresponding to peripheral or central nervous system pathology, and the paradoxical occurrence of pain and hypersensitivity phenomena within the denervated zone and its surroundings.1 These sensory phenomena are seen across aetiologically different conditions and across different locations of the nerve lesion. Rarely, if ever, can one single mechanism be claimed to be responsible for generating and maintaining the symptoms and signs seen in neuropathic pain.2,3 Treatment of neuropathic pain is still difficult despite new treatments, and there is no single treatment that works for all conditions and their underlying mechanisms.

1 Jensen TS, Gottrup H, Sindrup SH, Bach FW: The clinical picture of neuropathic pain. European Journal of pharmacology, 2001; 429: 1-11
2 Jensen TS, Baron R: Translation of symptoms and signs into mechanisms in neuropathic pain. Pain,  2003; 102: 1-8
3 Woolfe CJ: Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. Life Sciences, 2004; 74:2605-2610

last update:  07 Sep 2010