Pathophysiology & Conditions

Hypersensitivity as an identifying Feature

Chronic pain is a complex phenomenon. It results from a sustained sensory abnormality caused by an ongoing peripheral process such as chronic inflammation; however, it can also occur independently of the trigger that initiated it. A general distinctive feature is hypersensitivity, which can result from two principles: either the response to an injurious stimulus is increased, resulting in exaggerated and prolonged pain, or the thresholds are reduced, leading to pain production in response to normally non-injurious stimuli. In both cases, the responsive pain system is altered, resulting in chronic pain.1 The longer the pain lasts, the lower the chance of an entire normalisation of the nervous system. As a result, patients may develop a “pain memory”, leading to persisting pain although the injury has already healed.

Typical chronic pain conditions are: cancer pain, low back pain, arthritis pain, osteoporotic pain, neuropathic pain

1 Woolf CJ: Somatic Pain – Pathogenesis and Prevention. British Journal of Anaesthesia, 1995; 75:169-76

M-N/A-UK-10-18-0001       Date of preparation October 2018

last update:  17 May 2019